|
Indications and Dosage
Oral
Hyperlipidaemias Adult: 100-200 mg tid, adjust dose based on patient's age and symptoms. Oral Symptoms associated with hypertension, Symptoms associated with cerebral arteriosclerosis and sequelae of cerebral apoplexy, Peripheral circulatory disturbance resulting from arteriosclerosis obliterans Adult: 100-200 mg tid, adjust dose based on patient's age and symptoms.
|
|
Adverse Reactions
Nausea, diarrhoea, constipation, stomach ache/discomfort, anorexia, rash, flushing, oedema, and liver dysfunction (elevated AST, ALT).
|
|
Food Interaction
Higher absorption when administered after a meal.
|
|
Action
Description: Tocopheryl nicotinate is the esterified compound of tocopherol and nicotinic acid which has more potent pharmacological activity than a dose of both drugs given concurrently. Tocopheryl nicotinate is a lipid regulating drug which can reduce total serum cholesterol and triglycerides, and increase HDL cholesterol. It has also been shown to enhance microcirculation, inhibit platelet aggregation, prevent capillary fragility, and restore arterial oxygen partial pressure.
Pharmacokinetics: Absorption: Following a single oral admin of 600 mg dose, Tmax of Tocopheryl nicotinate (unchanged form): About 6 hr; tocopherol (hydrolysed form): About 10 hr. Excretion: Elimination half-life of Tocopheryl nicotinate: About 4.3 hr; tocopherol (hydrolysed form): About 38.5 hr. |
|
Storage
Store at room temperature. Protect from heat and moisture.
|
Sign Out
